Microb-Manager helps you to regain balance over the whole-body microbiome with its powerful botanical blend that helps manage microbial health and related immune responses. Delivered in rapid-absorbing, nanotech-enhanced softgels.*
Microb-Manager™ is a patent-pending, premier immune support formula that promotes a healthy microbial balance.
Artemisinin, berberine, broad spectrum hemp extract, and Andrographis offer potent systemic antimicrobial properties, while our proprietary curcuminoid complex and Boswellia extract balance the inflammatory response to infection. Milk thistle and quercetin enhance liver function and balance mast cell activity, while Andrographis and propolis are immunomodulatory and support a resilient internal terrain.
BENEFITS & APPLICATIONS:
• Antimicrobial – targets harmful bacteria, viruses, fungi, and parasites 5,37,12,14,22,29,31
• Anti-inflammatory – Suppresses pro inflammatory cytokines that may be triggered by infections38,39
• Immunomodulatory – Supports a healthy immune response 40,41
• Stabilizes mast cells and prevents histamine overactivity 25
• Supports liver function and detoxification 42
• Effective for acute and chronic microbial infections
BOTANICALS: THE WAY OF THE FUTURE FOR MANAGING MICROBES
The invention of pharmaceutical antibiotics in the 20th century has dramatically changed our world. Vast reductions in infectious disease mortality and morbidity have come at the cost of bacterial antibiotic resistance, now considered a “global crisis.”1 In the United States, two million people acquire antibiotic-resistant infections each year; this number continues to rise.2 The dwindling efficacy of pharmaceutical antibiotics has led to a resurgence of scientific interest in traditional medicinal plants for supporting the body’s antimicrobial defenses.3 Unlike antibiotics, plant extracts utilize multiple mechanisms to
selectively target pathogenic microbes, reducing the risk of antibiotic resistance while promoting a healthy microbial balance.
TIME-HONORED BOTANICALS WITH POTENT ANTIMICROBIAL ACTIVITY
Artemisia annua, an intensely bitter and aromatic botanical, has been used for thousands of years in Traditional Chinese Medicine for the treatment of chills and fever of an infectious origin. Its primary active ingredient, artemisinin, has potent antimalarial activity and is the basis for artesunate, a synthetic antimalarial drug. However, artemisinin also has formidable antimicrobial activity against a variety of other pathogens, including periodontal microbes and Staphylococcus aureus. It is also a candidate drug against Borrelia burgdorferi, the cause of Lyme disease, and has antioxidant and anti-inflammatory properties.4,5,6 Artemisinin’s ability to block the cellular multidrug efflux system in bacteria, involved in the development of antibiotic resistance, makes it an especially valuable botanical in the modern-day clinician’s antimicrobial toolkit.7
Berberine, the bitter yellow alkaloid found in the roots and bark of various Berberis species, also has potent antimicrobial activity against oral pathogens, Candida species, and gastrointestinal pathogens, not to mention its long history of use for inflammatory conditions.8,9
Cinnamon essential oil is also antimicrobial. With activity against Borrelia burgdorferi, H. pylori, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and Candida albicans.10,11
Together, these three powerful botanicals support the systemic elimination of microbes and parasites involved in both acute and chronic infections, restoring a healthy internal ecosystem.
THE ANTIBACTERIAL BENEFITS OF PHYTOCANNABINOIDS
The hemp-based phytocannabinoid CBD is well-known for its analgesic and anti-inflammatory properties. CBD is also a potent antimicrobial, inhibiting the growth of Staphylococcus aureus and Streptococcus pneumoniae with a potency similar to that of vancomycin and daptomycin.12 The antimicrobial and anti-inflammatory activity of CBD, make hemp extract an attractive option for treating infections while also minimizing the harmful effects of pathogen-induced inflammation on the body.
MODULATE CYTOKINE RESPONSE WITH TRADITIONAL BOTANICALS
Infections induce a profound inflammatory response within the body. While this inflammatory response is intended to harm pathogens, impairing their survival, ongoing inflammation in the body can be destructive. Botanicals with dual antimicrobial and anti-inflammatory properties limit microbial survival while tempering the body’s response to physical irritations.
Curcuminoids, including curcumin and turmeric essential oils, are found in the brilliant yellow rhizome of Curcuma longa. They possess a wide range of pharmacological activities, including antimicrobial and anti-inflammatory effects. Curcumin inhibits the growth of Staphylococcus aureus, E. coli, Salmonella, and Candida while simultaneously decreasing pro-inflammatory cytokines.13,14,15 It also potentiates the antimicrobial activity of artemisinin.16 Turmeric essential oils enhance curcumin bioavailability and possess unique anti-inflammatory properties.17
Boswellia, the fragrant resin from the Boswellia serrata tree, has been used for millennia in Indian Ayurvedic medicine for the treatment of chronic inflammatory illnesses. It too possesses an impressive array of antimicrobial activities, inhibiting the growth of Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Klebsiella pneumonia, Pseudomonas aeruginosa, and Proteus vulgaris.18 It also inhibits oral pathogens and biofilm formation, while modulating inflammatory pathways triggered by infection.19,20,21,22 Interestingly, a combination of curcumin and Boswellia extract is more potent than either compound alone for supporting a healthy cytokine response.23
MILK THISTLE AND QUERCETIN OFFER LIVER AND MAST CELL SUPPORT
Microbial pathogens have damaging effects on the liver, impairing the liver’s natural detoxification capacities. Milk thistle is profoundly hepatoprotective, supporting liver function while also balancing the immune system and systemic inflammatory responses.24 The polyphenol quercetin, found in edible plants ranging from green tea to apples, stabilizes mast cells, which are often hyper-reactive in individuals with chronic infections. Natural mast cell stabilization may help the most sensitive patients better tolerate medications and supplements, improving adherence to protocols.25,26
BUILD A RESILIENT INTERNAL TERRAIN
French microbiologist Louis Pasteur, famous for his germ theory of disease, is purported to have stated on his deathbed that “the terrain is everything.” His simple but profound statement alluded to the importance of a robust internal environment, including a healthy immune system, as the best defense against disease.
Andrographis and propolis are rich sources of immunomodulatory compounds that support a healthy internal terrain, fortifying the body against microbial stressors. Andrographolide, a primary constituent of Andrographis, has potent immune-stimulating, antimicrobial, and anti-inflammatory properties.27,28,29 Propolis, a resinous mixture produced by honeybees, has immunomodulatory, antibacterial, antiviral, and antifungal effects.30,31,32
UNPARALLELED BIOAVAILABILITY WITH SEDS
Artemisinin, phytocannabinoids, berberine, curcuminoids, and Boswellia typically have poor oral bioavailability. However, emerging research indicates that their bioavailability is dramatically enhanced when they are bound to lipid molecules.33,34,35,36,23 Quicksilver Scientific’s innovative self-emulsifying delivery system (SEDS) combines these potent botanicals in a softgel capsule that emulsifies on contact with digestive system juices. Unlike many dietary supplements in which antimicrobial action is limited to the gastrointestinal tract, our emulsified nanoparticles easily diffuse through intestinal cell membranes into the bloodstream, offering rapid systemic support for healthy microbial, inflammatory and immune balance.